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Academic Staff |
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Contact Details |
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Department of Cancer Biology (Research)
Direct :
079-22688000 ; 079-22690000
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Services :

Besides research and educational activities, the major thrust of the division is to provide routine
clinical diagnostic services for cancerous and non-cancerous patients referred to our institute. The
diagnostic services includes are analysis of various tumor markers, thyroid and hormone profiles which are
performed on Chemiluminescence System Cobas e 411Immunoanalyser.
Clinical Activities :
The Division is NABL Accredited for Special
Biochemistry Investigations. At the division,
clinical evaluation of total 23 different parameters
are being routinely carried out to aid diagnosis and
treatment of cancer patients as well as patients
with endocrine disorders.
Academic Activities : The division participates in various academic
activities of the institute; weekly seminars of the
department, enrolment of PhD students and
MSc/MPharm Dissertation students, and Summer
Training Programme for MSc/BSc students. Postgraduates
from various universities of Gujarat are
enrolled for dissertation work and undergraduates
as observers for Summer Training
Programme. Moreover, the division is actively
involved in recently started MSc Cancer Biology
course. Lectures and practicals, for students of MSc
Cancer Biology are being organized by the division.
The division participates in Conferences and CME
organized by the Cancer Biology Department.
Research Activities :
Biomarkers are central to detection, diagnosis and
management of cancer and hold vast potential for
the development of effective new personalized
cancer therapies. For this, it is necessary to define the cumulative genetic events and how genes work,
particularly, genomic instability, genes involved in
deregulation of signal transduction, transcription
factors, cell cycle regulatory and DNA damage and
response pathways, and evaluate their clinical
relevance. At present, the research activities of this
division are focused at studying the clinical
relevance of multiple biologic markers by fully
exploiting the genetic machinery involved in the
initiation and progression of cancer along with
tumor micro environment us in grecent
technologies. In breast and oral cancer, research
revolves around the vital role of Jak-Srcs-Stats and
cytokine signal transduction pathway mediated by
EGFR, DNA damage repair pathways, stem cell
markers, their interaction with microRNAs, and
sub sequently it srelevance for patient
management. In colorectal cancer, the role of Fas
receptor and its ligand, Sparc receptors, vitamin D
receptors, Thymidine synthetase and ERCC-1 gene
polymorphism will be exploited. The information
gained will be valuable for a more reliable estimate
of tumor behaviour to predict patients’ prognosis,
identify individual patients who are at a low risk or
high risk of relapse, detection of micrometastasis
and monitoring the course of the disease. In
thyroid malignancies, the role of cytokines
involved in pathogenesis of the disease is exploited.
Subsequently statistical analysis of the data is
performed. |